What do you say?

你的意思怎么样？

原句： What do you think?

So what?

那又怎么样？

原句： What can you do about it?

What's up?

有什么事情吗？

原句： Anything happen?

What's new?

有什么吗？

原句： Any new developments?

You'd better wise up.

放聪明点。

原句：You'd better do as I say.