estrange
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vt.
1. 使疏远;使感情失和[(+from)]
His foolish behavior estranged all his friends.
他的愚蠢行为令所有的朋友与之疏远。
The argument estranged him from his wife.
这一争论使他同妻子疏远了


estrangement
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n.
1. 疏远;失和,不和[(+from/between)]
The quarrel led to a complete estrangement between her and her family.
这一争吵使她同家人完全疏远了。